Main Article Content

Abstract


ABSTRACT
Introduction. Due to late referral of the pads to the nephrologist and the lack of medical follow-up, many patients are admitted with complications from kidney disease requiring the urgent start of hemodialysis. The aim of this work was to study the clinico-biological and evolutionary profile of patients with Acute Kidney Injury (AKI) who underwent emergency hemodialysis in a referral hospital of Ivory Coast. Methods. This was a retrospective, descriptive and analytical study which took place from January 1 to December 31, 2016, in the Nephrology Department at the University Teaching Hospital of Yopougon in Ivory Coast. All patients who received an emergency hemodialysis session during the study period were identified through the registry. Those who were at their first session for AKI, at least 16 years old and whose clinical records were available were selected. Results. We collected 36 medical records of patients with an average age of 41.31±13.93 years. Patients past medical history showed high blood pressure (HBP) (27.78%), herbal medicine consumption (80.56%) and HIV infection (19.44%). The main clinical signs were Elevated BP (38.89%), neurogical disorders (41.66%), edema (22.22%) with sometimes acute pulmonary edema (2,78%) and anuria (19.44%). Organic AKI accounted for more than 80% of cases. The main indications of hemodialysis were: uremic encephalopathy (41.67%), other severe uremic complications (25%), persistent anuria (19.44%) and threatening hyperkaliemia (11.11%). Death occurred in 30.55% with sepsis as the main cause (72.72%). Conclusion. AKI requiring hemodialysis is associated with high mortality and deaths were more often caused by sepsis.
RÉSUMÉ
Introduction. Le retard accusé pour leur prise en charge fait que nombreux sont les patients souffrant d’insuffisance rénale qui arrivent dans les hôpitaux avec des complications sévères nécessitant des séances d’hémodialyse en urgence. Le but de ce travail était d’étudier le profile clinico-biologique et évolutif des patients atteints de lésion rénale aiguë (LRA) et hémodialysés en urgence dans un hôpital de référence en Côte d’Ivoire. Méthode. Il s’est agi d’une étude rétrospective, descriptive et analytique qui s’est déroulée du 1er janvier au 31 décembre 2016 dans le service de néphrologie du CHU de Yopougon en Côte d’Ivoire. Tous les patients qui étaient à leur première séance d’hémodialyse pour une LRA et âgés de plus de 16 ans ont été inclus dans l’étude. Résultats. Nous avons colligé 36 patients avec un âge moyen de 41.31±13.93 ans. Les principaux antécédents des patients étaient une HTA (27,78 %), une consommation de médicaments traditionnels (80,56 %) et une infection au VIH (19,44 %). Les principaux signes cliniques étaient l’HTA (38,89 %), les troubles neurologiques (41,66 %), les œdèmes (22,22 %) avec l’OAP (2,78 %) et l’anurie (19,44 %). La LRA était organique dans plus de 80 % des cas. Les principales indications de l’hémodialyse étaient l’encéphalopathie urémique (41,67 %), les autres complications urémiques (25 %), l’anurie persistante (19,44 %), l’hyperkaliémie menaçante (11,11 %). La mortalité était de 30,55 % et le sepsis en était la principale cause. Conclusion. La LRA nécessitant une hémodialyse en urgence était associée à une forte mortalité et le sepsis le plus souvent incriminée.

Keywords

Acute kidney injury Hemodialysis Emergency Insuffisance rénale aigue Hémodialyse Urgence

Article Details

How to Cite
François , K. P. ., Cyr, G. M. ., Tchoupé Djoumbissie Marius, Semde Aoua, Moudachirou Mohamed Ibrahim Alex, Ouedraogo Saidou, Togo Abdoulaye, Diopoh Patrick Sery, & Yao Kouame Hubert. (2022). Clinicobiological Profile and Evolution of Patients with Acute Kidney Injury Requiring Emergency Hemodialysis in an Ivorian Referral Hospital. HEALTH SCIENCES AND DISEASE, 23(4). https://doi.org/10.5281/hsd.v23i4.3522

References

  1. Levin A, Stevens PE. Summary of KDIGO 2012 CKD Guideline : behind the scenes , need for guidance , and a framework for moving forward. Kidney Int. 2013 ;85(1) :49‑61.
  2. Koza Y. Acute kidney injury: current concepts and new insights. J inj violence res. 2016;8(1):58‑62.
  3. Eckardt KU, Bansal N, Coresh J, Evans M, Grams ME, Herzog CA et al. Improving the prognosis of patients with severely decreased glomerular filtration rate (CKD G4+): conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int. 2018 Jun;93(6):1281-1292.
  4. Garnier F, Couchoud C, Landais P, Moranne O. Increased incidence of acute kidney injury requiring dialysis in metropolitan France. PLoS One. 2019 Feb 7;14(2): e0211541.
  5. Mehta RL, Cerdá J, Burdmann EA, Tonelli M, García-García G, Jha V et al. International Society of Nephrology's 0by25 initiative for acute kidney injury (zero preventable deaths by 2025): a human rights case for nephrology. Lancet. 2015 Jun 27;385(9987):2616-43. doi: 10.1016/S0140-6736(15)60126-X. Epub 2015 Mar 13. PMID: 25777661.
  6. Yaya K, Mokhtar Mbacké LM, Moussa Tondi ZM, Tall LA, Maria F, Moustapha CM et al. Décentralisation De La Dialyse Au Sénégal: Expérience D’1 An Du Centre De Tambacounda A l’Est Du Pays. European Scientific Journal 2016;12(36): 164-73
  7. Petitclerc T. Chronic hemodialysis: technical aspects and organizational modalities in Thervet E. Traité de Néphrologie. Paris, Editions Lavoisier Médecine Sciences 2017 p 597-601.
  8. Safari S, Hashemi B, Forouzanfar MM, Shahhoseini M. Epidemiology and Outcome of Patients with Acute Kidney Injury in Emergency Department; a Cross-Sectional Study. Emergency. 2018;6(1):1‑7.
  9. Igiraneza G, Ndayishimiye B, Nkeshimana M, Dusabejambo V, Ogbuagu O. Clinical Profile and Outcome of Patients with Acute Kidney Injury Requiring Hemodialysis: Two Years ' Experience at a Tertiary Hospital in Rwanda. Biomed Res Int. 2018 Mar 27;2018:1716420.
  10. Jamale TE, Hase NK, Kulkarni M, Pradeep KJ, Keskar V, Jawale S et al. Earlier-start versus usual-start dialysis in patients with community-acquired acute kidney injury: a randomized controlled trial. Am J Kidney Dis. 2013 Dec;62(6):1116-21.
  11. Barbar SD, Clere-Jehl R, Bourredjem A, Hernu R, Montini F, Bruyere R, Lebert C, Bohe J, Badie J, Eraldi JP, et al. Timing of renal-replacement therapy in patients with acute kidney injury and sepsis. N Engl J Med. 2018;379(15):1431–42.
  12. Adu D, Okyere P, Boima V, Matekole M, Osafo C. Community-acquired acute kidney injury in adults in Africa. Clinical Nephrology 2016;86:48-52.
  13. Bello B, Busari A, Amira C, Raji Y, Braimoh R. Acute kidney injury in Lagos: Pattern, outcomes, and predictors of in-hospital mortality. Niger J Clin Pract. 2017;20(2):194‑9.
  14. Lengani A, Kargougou D, Fogazzi GB, Laville M. Acute renal failure in Burkina Faso. Nephrol Ther. 2010;6(1):28‑34.
  15. Gaudry S, Hajage D, Benichou N, Chaïbi K, Barbar S, Zarbock et al. Delayed versus early initiation of renal replacement therapy for severe acute kidney injury: a systematic review and individual patient data meta-analysis of randomised clinical trials. Lancet. 2020 May 9;395(10235):1506-15.
  16. Charles S Ilboudo, Harouna Doro, Ismael Guibla, Farid Belem, Soumana Konate, Aoua Semdé et al. Prognosis of emergency hemodialysis patients in the nephrology and dialysis department of the Souro Sanou University Teaching Hospital (Bobo Dioulasso). Health Sci. Dis: Vol 22(6) June 2021 pp11-14.
  17. Vanmassenhove J, Kielstein J, Jörres A, Biesen WV. Management of patients at risk of acute kidney injury. Lancet. 2017 May 27;389(10084):2139-2151.

Most read articles by the same author(s)