Epidemiology and Clinical Presentation of Systemic Lupus in Bamako

Authors

  • Gassama M 2. Université de sciences techniques et de technologie de Bamako USTTB
  • Dicko AA 2. Université de sciences techniques et de technologie de Bamako USTTB
  • Sissoko M 1. Service de Dermatologie, Hôpital de Dermatologie de Bamako,
  • Traoré T 1. Service de Dermatologie, Hôpital de Dermatologie de Bamako,
  • Fofana Y 5. Hôpital régional de Mopti, Mali
  • Cissé L 1. Service de Dermatologie, Hôpital de Dermatologie de Bamako,
  • Guindo B 1. Service de Dermatologie, Hôpital de Dermatologie de Bamako,
  • Keita A 1. Service de Dermatologie, Hôpital de Dermatologie de Bamako,
  • Traoré AA 1. Service de Dermatologie, Hôpital de Dermatologie de Bamako,
  • Dao K 3. Service de Médecine Interne, Hôpital Gabriel Touré
  • Samaké A 1. Service de Dermatologie, Hôpital de Dermatologie de Bamako,
  • Diarra M 1. Service de Dermatologie, Hôpital de Dermatologie de Bamako,
  • Guindo H 4. Hôpital régional de Gao, Mali
  • Diakité M 1. Service de Dermatologie, Hôpital de Dermatologie de Bamako,
  • Faye O 2. Université de sciences techniques et de technologie de Bamako USTTB

DOI:

https://doi.org/10.5281/hra.v2i4.5477

Keywords:

lupus systémique, Bamako, Aspects épidémiologiques

Abstract

RÉSUMÉ
Introduction. Le lupus systémique, également appelé lupus érythémateux disséminé, est une maladie auto-immune chronique qui affecte principalement les articulations, la peau, les reins, le cœur, les poumons et le système nerveux. L’objectif de notre étude était de décrire le profil épidémio-clinique des cas de lupus systémique dans le service de Dermatologie à l’Hôpital de Dermatologie de Bamako (HDB). Méthodologie. Il s’agissait d’une étude transversale descriptive portant sur les cas de Lupus érythémateux systémique dans le service de dermatologie de l’HDB sur une période de12 mois allant du 01 mars 2018 au 21 mars 2019 portant sur tout patient atteint de lupus systémique. Résultats. Nous avons recensé 33 malades avec un sex-ratio de 0,10 et un âge moyen de 42ans.Les signes cliniques les plus retrouvés étaient des éruptions en aile de papillon (100%) ou discoide (96,97%). Les signes biologiques les plus retrouvés étaient la présence d’une anémie inflammatoire (27,2%) et des anticorps anti DNA natifs (90,91%). Conclusion. Cette étude souligne l'importance de la reconnaissance précoce et de la prise en charge adéquate du lupus systémique pour améliorer la qualité de vie des patients.
ABSTRACT
Introduction. Systemic lupus erythematosus, also known as systemic lupus, is a chronic autoimmune disease that mainly affects the joints, skin, kidneys, heart, lungs, and nervous system. The aim of our study was to describe the epidemiological and clinical profile of cases of systemic lupus in the Dermatology Department at the Bamako Dermatology Hospital (HDB). Methodology. This was a descriptive cross-sectional study of cases of systemic lupus erythematosus in the dermatology department at the HDB over a period of 12 months from March 01, 2018 to March 21, 2019 involving all patients with systemic lupus. Results. We identified 33 patients with a sex ratio of 0.10 and a mean age of 42 years. The most common clinical signs were butterfly rash (100%) or discoid rash (96.97%). The most common biological markers were the presence of inflammatory anemia (27.2%) and native DNA antibodies (90.91%). Conclusion. This study highlights the importance of early recognition and appropriate management of systemic lupus to improve the quality of life of patients.

References

Meyer O, Kahn MF. Lupus erytemateux disseminé .In : Kahn MF,peltier AP, Meyer O, piette J C, editors. Les maladies systemiques .Paris: Flammarion – Médecine sciences ; 2000. P131-368.

MOK C.C. Lau CS. PATHOGENESIS of systemic lupus erythematosus, Review.J Clinpathol 2003; 56; 481-90.

Hochberg M C. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. ARTHRISIS Rheum1997;40:1725

Zeinab. ZianZ , Maamar M, Mohamed El Aouni, Amina Barakat, Naima Ghailani Nourouti, Rajae El Aouad, Naima Arji, and Mohcine Bennani Mechita .Immunological and Clinical Characteristics of Systemic Lupus Erythematosus: A Series from Morocco. https://doi.org/10.1155/2018/3139404

TAHAR R. Lupus érythémateux systémique : Aspects épidemio- cliniques, biologiques et évolutifs au cours des consultations dans le service de RHumatologie au CHU du point G. 2005-2006 P.75-76.

Arnaud L, Fagot SP, Mathian A,Parta M. Fagot-compagnie , Amomuz prevalence and incidence of systemic lupus erythematosus influence: a 2010 Nation Wide population basset study Auto immun rev 2014;13(11): 1082-1089.

C. Sardu, E. Cocco, A. Mereu et al., “Population based study of 12 autoimmune diseases in Sardinia, Italy: Prevalence and comorbidity,” PLoS ONE 2012, vol. 7, no. 3.

I. Gergianaki, A. Fanouriakis, A. Repa et al., “Epidemiology and burden of systemic lupus erythematosus in a Southern European population: data from the community-based lupus registry of Crete, Greece,” Annals of the Rheumatic Diseases 2O17, vol. 76, no. 12, pp. 1992–2000.

Moroni l, bianchi I, ijeoa. geoépidemiology, denderand auto immune disease.auto immune rev 2012 ;11 : A386-392.

Oertelt-prigione. The influence of the sex and gender on the auto immune response. Auto immune rev 2012; 11 A386-92. Lee TP, Chiang BL. Sex differences in spontaneous versus induced animal models of autoimmunity. Autoimmun Rev 2012; 11: A422–429.

K A M, Diallo S, Kane A, Wade B M BENGUE M, DioufB, Diallo A, Dop TM, Lupus erytemateux systemique au Sénégal Med Afriq noire : 1998,(45 ) 42-45.

Cervera R, Khamashtab M,FontJ, Sebiastani GD, Gil A, Lavilla P et al.

Systemic lupus erythematosus:clinical and immunologic patterns of disease expression in a cohort of 1 000 patients. Medicine1993; 72: 113-124.

BIONIS E Carol. Auto anticorps. Document disponible en ligne consulté le 15 janvier 2019 sur le site www.biomnis.com

Magro R,Borg A. Characterisation of Patients with Systemic Lupus Erytematosus in Malta: A Population Based Cohort Cross-Sectional Study. BioMed Research International 2018;https://doi.org/10.1155/2018/2385386.

Mok CC, Lau CS. Lupus in Hong Kong Chinese.Lupus 2003;12:717-22.

Boey ML, Peebles CL, Tsay G, Feng PH, Tan EM. Clinical and autoantibody correlations in Orientals with systemic lupus erythematosus. Ann Rheum Dis1988;47:918-23.

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Published

28-03-2024

How to Cite

Gassama M, Dicko AA, Sissoko M, Traoré T, Fofana Y, Cissé L, Guindo B, Keita A, Traoré AA, Dao K, Samaké A, Diarra M, Guindo H, Diakité M, & Faye O. (2024). Epidemiology and Clinical Presentation of Systemic Lupus in Bamako . HEALTH RESEARCH IN AFRICA, 2(4). https://doi.org/10.5281/hra.v2i4.5477

Issue

Vol. 2 No. 4 (2024): Health Research in Africa

Section

Research Articles

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