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Background and Objectives: IgA deficient patients are at risk of severe life-threatening anaphylactic reaction on being transfused blood or blood products. This study aimed at assessing the prevalence of IgA deficiency in blood donors in Yaounde, Cameroon.


Methods: Serum samples were collected from 670 apparently healthy blood donors. Enzyme linked Immunosorbent Assay (ELISA) was used to quantitate total IgA concentration.


Results: Of the 670 samples tested, 536 (80%) were from males and 134 (20%) from females. Age ranged from 17 to 58 with a mean of 28.3 ± 7years. There were no patients with IgA deficiency (IgA <5mg/dL); 11 persons (1.6%) with partial IgA deficiency (5-30mg/dL); 535 (79.9%) with normal IgA (31-450mg/dL) and 124 (18.5%) with greater than normal IgA levels. The concentration of IgA varied by sex, with females having significantly higher levels than males (p=0.002). The mean IgA

concentration generally increased with increasing age, p=0.001).


Conclusion: This study suggests that IgA deficiencies are rare in the study group and may not be a major clinical concern in our setting.


Immunoglobulin A levels Blood donors Serum samples IgA deficiency Cameroon.

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Okomo Assoumou, M. C., Akongnwi Mugyia, E., Esiène, A., Ikomey Mondinde, G., Mesembe, M., Adiogo, D., Atashili, J., E Lyonga, E., Eyoh, A., & Ndumbe, P. (2013). IMMUNOGLOBULIN A (IGA) LEVELS IN HEALTHY BLOOD DONORS IN YAOUNDE, CAMEROON. HEALTH SCIENCES AND DISEASE, 12(4). Retrieved from


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