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Abstract

Background and Objectives: IgA deficient patients are at risk of severe life-threatening anaphylactic reaction on being transfused blood or blood products. This study aimed at assessing the prevalence of IgA deficiency in blood donors in Yaounde, Cameroon.

 

Methods: Serum samples were collected from 670 apparently healthy blood donors. Enzyme linked Immunosorbent Assay (ELISA) was used to quantitate total IgA concentration.

 

Results: Of the 670 samples tested, 536 (80%) were from males and 134 (20%) from females. Age ranged from 17 to 58 with a mean of 28.3 ± 7years. There were no patients with IgA deficiency (IgA <5mg/dL); 11 persons (1.6%) with partial IgA deficiency (5-30mg/dL); 535 (79.9%) with normal IgA (31-450mg/dL) and 124 (18.5%) with greater than normal IgA levels. The concentration of IgA varied by sex, with females having significantly higher levels than males (p=0.002). The mean IgA

concentration generally increased with increasing age, p=0.001).

 

Conclusion: This study suggests that IgA deficiencies are rare in the study group and may not be a major clinical concern in our setting.

Keywords

Immunoglobulin A levels Blood donors Serum samples IgA deficiency Cameroon.

Article Details

How to Cite
Okomo Assoumou, M. C., Akongnwi Mugyia, E., Esiène, A., Ikomey Mondinde, G., Mesembe, M., Adiogo, D., Atashili, J., E Lyonga, E., Eyoh, A., & Ndumbe, P. (2013). IMMUNOGLOBULIN A (IGA) LEVELS IN HEALTHY BLOOD DONORS IN YAOUNDE, CAMEROON. HEALTH SCIENCES AND DISEASE, 12(4). Retrieved from https://www.hsd-fmsb.org/index.php/hsd/article/view/118

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