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Hepatocellular carcinoma accounts for more than 85% of primary liver cancers. Recently, progresses in diagnostic modalities and therapeutic procedures have prolonged the survival in patients with HCC. Bone involvement is reported as uncommon in HCC. Axial skeleton is the most frequent localization of bone metastases. Few reports have appeared in the literature concerning patients who presented with skeletal metastases as the clinical manifestation of HCC. We describe our experience with two patients with skeletal metastases as the dominant clinical manifestation of hepatocellular carcinoma.

Le carcinome hépatocellulaire (CHC) représente plus de 85% des cancers primitifs du foie. Récemment, les progrès réalisés sur les plans diagnostique et thérapeutique ont permis de prolonger la survie des patients atteints de CHC. L'atteinte osseuse est signalée comme peu fréquente dans le CHC. Le squelette axial est la localisation la plus fréquente des métastases osseuses. Peu d’études dans la littérature concernent les patients qui présentent des métastases squelettiques comme une manifestation clinique du CHC. Nous rapportons notre expérience avec deux patients présentant des métastases squelettiques comme manifestation clinique dominante du CHC.


Hepatocellular carcinoma bone metastases Togo

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Aklesso, B., Lawson-ananissoh, L. M., Lidawu Kogoe, R., El Hadji Yacoubou, R., Redah, D., & Laconi Kaaga, Y. (2020). Bone Metastases as the Main Clinical Manifestation of Hepatocellular Carcinoma : A Report of Two Cases. HEALTH SCIENCES AND DISEASE, 21(7). Retrieved from


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