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RÉSUMÉ
Introduction. Au Cameroun, le nombre d’enfants sous antirétroviraux (TARV) est en progression régulière. Les ARV sont responsables d’effets indésirables avec risque de maladies cardiovasculaires Le but de ce travail est d’identifier les facteurs associés à hypertension artérielle (HTA) chez les enfants sous TARV dans la ville de Yaoundé. Méthodes. Nous avons réalisé une étude transversale de novembre 2016 à juin 2017 dans la ville de de Yaoundé. Etait inclus tout enfant âgé entre six et quinze ans révolus et sous ARV depuis au moins un an. Le critère de jugement était la TA élevée. Les tests de Chi carré et de Fisher ont été conduits ainsi qu’une régression logistique, avec seuil de significativité de p <0,05. Résultats. Nous avons enrôlé 100 enfants dont l’âge moyen est 10,81 ± 2,72 ans La prévalence de l’HTA est de 5%, la pré HTA est à 12%. La durée de TARV de plus de neuf ans [OR=6,21 (IC 95 : 1,62-23,70)], la durée d’infection à VIH de plus de 11 ans [OR= 5,75 (IC 95 : 1,75-18,88)], l’âge avancé [OR=3,57 (IC 95 : 0,95-13,34)] et le temps de sédentarité important [OR=3,42 (IC 95 : 0,99-11,98)] étaient associés aux chiffres tensionnels élevés mais la régression logistique n’a pas confirmé cette association. Conclusion. L’HTA est présente chez les enfants sous TARV à Yaoundé mais il n’a pas été retrouvé de facteurs associés à cet état. Cependant, les facteurs de risques de maladies cardiovasculaires sont présents chez ces enfants et leur suivi devrait en tenir compte.
ABSTRACT
Introduction. In Cameroon, the number of children on antiretrovirals (ART) is steadily increasing. ARVs are responsible for adverse effects with risk of cardiovascular disease The aim of this work is to identify the factors associated with high blood pressure(HBP) in children on ART in Yaoundé. Methods. We carried out a cross-sectional study from November 2016 to June 2017 in the city of Yaoundé. Included were all children between the ages of six and fifteen who had been on ARVs for at least one year. The endpoint was elevated BP. Chi-square and Fisher tests were conducted as well as a logistic regression, with a significance level of p <0.05. Results. We enrolled 100 children whose average age is 10.81 ± 2.72 years. The prevalence of HBP is 5%, pre hypertension is 12%. The duration of ART of more than nine years [OR=6.21 (95% CI: 1.62-23.70)], the duration of HIV infection of more than 11 years [OR= 5.75 (95% CI: : 1.75-18.88)], advanced age [OR=3.57 (95% CI: 0.95-13.34)] and significant sedentary time [OR=3.42 (95% CI: 0.99-11.98)] were associated with elevated BP but logistic regression did not confirm this association. Conclusion. HBP is present in children on ART in Yaoundé but no factor associated with this condition have been found. However, risk factors for cardiovascular disease are present in these children and their follow-up should take this into account.

Keywords

High blood pressure Children HIV ART Hypertension artérielle Enfants VIH ARV

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Kamgaing Nelly, Fouogue Véronique, Kalla Claude, Kamgaing Rachel, Monebenimp Francisca, & Ndjolo Alexis. (2023). Facteurs Associés à l’Hypertension Artérielle chez les Enfants Vivant avec le VIH et Sous Traitement Antirétroviral dans la ville de Yaoundé. HEALTH SCIENCES AND DISEASE, 24(6). https://doi.org/10.5281/hsd.v24i6.4513
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References

  1. Piloya T, Bakeera-Kitaka S, Kekitiinwa A, Kamya MR. Lipodystrophy among HIV-infected children and adolescents on highly active antiretroviral therapy in Uganda: a cross sectional study. J Int AIDS Soc 2012;15:17427. https://doi.org/10.7448/IAS.15.2.17427.
  2. Noubiap JJ, Essouma M, Bigna JJ, Jingi AM, Aminde LN, Nansseu JR. Prevalence of elevated blood pressure in children and adolescents in Africa: a systematic review and meta-analysis. The Lancet Public Health 2017;2:e375–86. https://doi.org/10.1016/S2468-2667(17)30123-8.
  3. CNLS. RAPPORT ANNUEL 2014 DES ACTIVITES DE LUTTE CONTRE LE VIH/SIDA ET LES IST AU CAMEROUN. 2015.
  4. Chelo D, Wawo E, Siaha V, Anakeu A, Ateba Ndongo F, Koki Ndombo PO, et al. Cardiac anomalies in a group of HIV-infected children in a pediatric hospital: an echocardiographic study in Yaounde, Cameroon. Cardiovasc Diagn Ther 2015;5:444–53. https://doi.org/10.3978/j.issn.2223-3652.2015.11.03.
  5. Nampijja D, Kumbakumba E, Bajunirwe F, Kiwanuka J. Dyslipidemia and its Correlates among HIV Infected Children on HAART Attending Mbarara Regional Referral Hospital. Int Clin Pathol J 2017;4:00098. https://doi.org/10.15406/icpjl.2017.04.00098.
  6. Hardy ST, Urbina EM. Blood Pressure in Childhood and Adolescence. Am J Hypertens 2021;34:242–9. https://doi.org/10.1093/ajh/hpab004.
  7. Song P, Zhang Y, Yu J, Zha M, Zhu Y, Rahimi K, et al. Global Prevalence of Hypertension in Children. JAMA Pediatr 2019;173:1154–63. https://doi.org/10.1001/jamapediatrics.2019.3310.
  8. Chelo D, Mah EM, Chiabi EN, Chiabi A, Koki Ndombo PO, Kingue S, et al. Prevalence and factors associated with hypertension in primary school children, in the centre region of Cameroon. Transl Pediatr 2019;8:391–7. https://doi.org/10.21037/tp.2019.03.02.
  9. Tozo TAA, Gisi ML, Brand C, Moreira CMM, Pereira BO, Leite N. Family history of arterial hypertension and central adiposity: impact on blood pressure in schoolchildren. BMC Pediatr 2022;22:497. https://doi.org/10.1186/s12887-022-03551-4.
  10. Zhang Z, Ma J, Wang Z, Dong Y, Yang Z, Dong B, et al. Parental smoking and blood pressure in children and adolescents: a national cross-sectional study in China. BMC Pediatr 2019;19:116. https://doi.org/10.1186/s12887-019-1505-8.
  11. Meer R, Boateng D, Klipstein-Grobusch K, Norris SA, Kagura J. Incidence and correlates of high blood pressure from childhood to adulthood: the Birth to Twenty study. J Hypertens 2022;40:274–82. https://doi.org/10.1097/HJH.0000000000003004.
  12. Kingue S, Ngoe CN, Menanga AP, Jingi AM, Noubiap JJN, Fesuh B, et al. Prevalence and Risk Factors of Hypertension in Urban Areas of Cameroon: A Nationwide Population‐Based Cross‐Sectional Study. J Clin Hypertens (Greenwich) 2015;17:819–24. https://doi.org/10.1111/jch.12604.
  13. Gomwe H, Seekoe E, Lyoka P, Marange CS. Blood pressure profile of primary school children in Eastern Cape province, South Africa: prevalence and risk factors. BMC Pediatr 2022;22:207. https://doi.org/10.1186/s12887-022-03221-5.
  14. Katamba G, Agaba DC, Migisha R, Namaganda A, Namayanja R, Turyakira E. Prevalence of hypertension in relation to anthropometric indices among secondary adolescents in Mbarara, Southwestern Uganda. Italian Journal of Pediatrics 2020;46:76. https://doi.org/10.1186/s13052-020-00841-4.
  15. Vasudevan A, Thomas T, Kurpad A, Sachdev HS. Prevalence of and Factors Associated With High Blood Pressure Among Adolescents in India. JAMA Netw Open 2022;5:e2239282. https://doi.org/10.1001/jamanetworkopen.2022.39282.
  16. Jobe M, Agbla SC, Prentice AM, Hennig BJ. High blood pressure and associated risk factors as indicator of preclinical hypertension in rural West Africa. Medicine (Baltimore) 2017;96:e6170. https://doi.org/10.1097/MD.0000000000006170.
  17. de Andrade GN, Matoso LF, Miranda JWB, de Lima TF, Gazzinelli A, Vieira EW. Anthropometric indicators associated with high blood pressure in children living in urban and rural areas. Rev Lat Am Enfermagem n.d.;27:e3150. https://doi.org/10.1590/1518-8345.2760-3150.
  18. Quaresma FRP, da Silva Maciel E, dos Santos Figueiredo FW, Adami F. Factors associated with blood pressure disorders in Afro-descendant children and adolescents. BMC Pediatr 2019;19:244. https://doi.org/10.1186/s12887-019-1626-0.
  19. Díaz A, Calandra L. High blood pressure in school children and adolescents in Argentina over the past 25 years: A systematic review of observational studies. Arch Argent Pediatr 2017;115:5–11. https://doi.org/10.5546/aap.2017.eng.5.
  20. Warembourg C, Maitre L, Tamayo-Uria I, Fossati S, Roumeliotaki T, Aasvang GM, et al. Early-Life Environmental Exposures and Blood Pressure in Children. J Am Coll Cardiol 2019;74:1317–28. https://doi.org/10.1016/j.jacc.2019.06.069.
  21. Reuter CP, Rodrigues ST, Barbian CD, Silveira JF de C, Schneiders L de B, Soares SS, et al. High blood pressure in schoolchildren: Associated sociodemographic and biochemical factors. Rev Port Cardiol (Engl Ed) 2019;38:195–201. https://doi.org/10.1016/j.repc.2018.06.009.
  22. Riley M, Hernandez AK, Kuznia AL. High Blood Pressure in Children and Adolescents 2018;98.
  23. Beng H, Rakhmanina N, Moudgil A, Tuchman S, Ahn S-Y, Griffith C, et al. HIV-Associated CKDs in Children and Adolescents. Kidney International Reports 2020;5:2292–300. https://doi.org/10.1016/j.ekir.2020.09.001.
  24. Penda CI, Moukoko ECE, Koum DK, Moudze B, Fetchouang FVK, Abomo OE, et al. Prévalence de la Protéinurie et Facteurs Associés chez les En- fants et Adolescents Infectés par le VIH sous Traitement Anti- rétroviral à l’Hôpital Laquintinie de Douala, Cameroun 2018;19.
  25. Abd ElHafeez S, Bolignano D, D’Arrigo G, Dounousi E, Tripepi G, Zoccali C. Prevalence and burden of chronic kidney disease among the general population and high-risk groups in Africa: a systematic review. BMJ Open 2018;8:e015069. https://doi.org/10.1136/bmjopen-2016-015069.
  26. Harimenshi D, Niyongabo T, Preux P-M, Aboyans V, Desormais I. AFRAVIH2000110 Hypertension chez les patients infectés par le VIH recevant une thérapie antirétrovirale au Burundi., 2022.
  27. Nsanya MK, Kavishe BB, Katende D, Mosha N, Hansen C, Nsubuga RN, et al. Prevalence of high blood pressure and associated factors among adolescents and young people in Tanzania and Uganda. J Clin Hypertens (Greenwich) 2019;21:470–8. https://doi.org/10.1111/jch.13502.
  28. Lava SAG, Bianchetti MG, Simonetti GD. Salt intake in children and its consequences on blood pressure. Pediatr Nephrol 2015;30:1389–96. https://doi.org/10.1007/s00467-014-2931-3.
  29. Charakida M, Loukogeorgakis SP, Okorie MI, Masi S, Halcox JP, Deanfield JE, et al. Increased Arterial Stiffness in HIV-Infected Children: Risk Factors and Antiretroviral Therapy. Antiviral Therapy 2009;14:1075–9. https://doi.org/10.3851/IMP1437.
  30. Seaberg EC, Muñoz A, Lu M, Detels R, Margolick JB, Riddler SA, et al. Association between highly active antiretroviral therapy and hypertension in a large cohort of men followed from 1984 to 2003. AIDS 2005;19:953–60. https://doi.org/10.1097/01.aids.0000171410.76607.f8.
  31. Isa SE. Cardiovascular disease in HIV-infected patients: a focus on diabetes mellitus and hypertension? African Journal of Diabetes Medicine 2015;23.
  32. Frigati LJ, Jao J, Mahtab S, Asafu Agyei N-A, Cotton MF, Myer L, et al. Insulin Resistance in South African Youth Living with Perinatally Acquired HIV Receiving Antiretroviral Therapy. AIDS Res Hum Retroviruses 2019;35:56–62. https://doi.org/10.1089/aid.2018.0092.

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