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RÉSUMÉ
Introduction. La pandémie à COVID-19 a conduit à l’avènement de diffèrent vaccins dont il reste encore à évaluer les effets secondaires de ces vaccins. Le but de cette étude était d’examiner les facteurs associés à l’apparition des effets secondaires après la vaccination. Méthodologie. Nous avons mené une étude transversale auprès chez les participants après avoir la réception de la première dose de vaccin contre l’infection à COVID -19. Les participants volontaires ont été questionnés après les 72 heures premières heures après la vaccination sur les effets secondaires cliniques ressentis. L’analyse des facteurs associés aux effets secondaires a porté sur le type de vaccin, les facteurs sociodémographiques et médicaux. L’Odds ratio avec un intervalle de confiance a été utilisé pour mesurer ces associations. Résultats. L’étude a porté sur 462 sujets répartis entre trois sites de vaccination à Bamako. La tranche d’âge la plus représentée a été les moins de 30 ans, (275/462) soit 59,52% et le sexe féminin a été majoritaire soit (265/462) 57,36 % et (262/462) soit 56,70% des participants avaient un indice de masse corporelle normal. La majorité de nos participants avaient reçu un vaccin à adénovirus (186/462) soit 40,30 %. Nous avons trouvé que (256/462) soit 55,40% de nos sujets ont présenté des effets secondaires le premier jour de la vaccination et l’apparition était liée au type de vaccin. Le signe le plus fréquent a été la douleur du site d’injection (177/462) soit 55,62%. Conclusion. Les effets secondaires des vaccins contre COVID-19 sont liés au type de vaccins et les signes sont le plus souvent mineurs.
ABSTRACT
Introduction. The COVID-19 pandemic has led to the advent of different vaccines, the side effects of which have yet to be assessed. The aim of this study is to examine the factors associated with the occurrence of side effects after vaccination. Methodology. We conducted a cross-sectional study among participants after receiving the first dose of vaccine against COVID-19 infection. Voluntary participants were questioned after the first 72 hours after vaccination about the clinical side effects experienced. The analysis of factors associated with side effects focused on the type of vaccine, sociodemographic and medical factors. The odds ratio with a confidence interval was used to measure these associations. Results. The study was carried out on 462 subjects distributed between three vaccination sites in Bamako. The most represented age group was persons aged 30 years or less (275/462) or 59.52%. Most persons were women (265/462) or 57.36 %. More over, (262/462) or 56.70% of participants had a normal body mass index. The most common vaccine was an adenovirus vaccine (186/462) or 40.30%. We found that (256/462) or 64.3% of subjects experienced side effects after receiving the first dose and the appearance was related to the type of vaccine. The most common side effect was pain at the injection site (177/462) or 55.6%. Conclusion. The side effects of vaccines against COVID-19 are more related to the type of vaccines and the signs are most often minor.

Keywords

Side effect Covid-19 Vaccine pandemic Adenovirus messenger RNA vaccination site Effet secondaire Covid-19 Vaccin pandémie Adénovirus

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Tounkara M, Coulibaly S. L, Diarra A, Diallo M, Samake S, Sow F, Sissoko F, Tolofoudie M, Koumare M, Kamissoko B, Diallo B, Telly N, & Sangho O. (2023). Effets Secondaires Cliniques après l’Administration de la Première Dose de Vaccin contre la COVID-19 à Bamako. HEALTH SCIENCES AND DISEASE, 24(8). https://doi.org/10.5281/hsd.v24i8.4673
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