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Abstract

Abstract
Subacute sclerosing panencephalitis (SSPE) is a rare progressive, invariably fatal long-term complication of measles infection. It can manifest three to ten years after the acute infection. It results from mutation in the measles virus protein, and inappropriate immune response. We report the case of a 12 year old adolescent with no past history of measles; but in whom the diagnosis of SSPE was made on the basis of the clinical presentation, electroencephalogram results and the detection of anti measles antibodies in cerebrospinal fluid. SSPE should therefore be considered, in a patient with cognitive impairment and myoclonus in a context where measles is not rare even in the absence of history of measles.

Résumé
La panencéphalite sclérosante subaigüe (PESS) est une complication à long terme de la rougeole. C’est une complication rare, mais invariablement fatale. Elle se manifeste trois à dix ans après l’infection aigue. Elle résulte d’une mutation dans la protéine de virus de la rougeole associée à une réponse immunitaire inappropriée. Nous rapportons le cas d'une adolescente de 12 ans sans antécédents de rougeole; mais chez qui le diagnostic de PESS a été fait sur la base de la présentation clinique, des résultats de l’électroencéphalogramme et de la détection des anticorps anti-rougeoleux dans le liquide céphalorachidien. Le diagnostic de PESS devrait être évoqué chez un patient souffrant de troubles cognitifs et de myoclonies dans tout contexte où la rougeole n’est pas rare, même en l'absence d’antécédents de rougeole.

Keywords

subacute sclerosing panencephalitis measles myoclonic jerks electroencephalogram anti measles antibodies

Article Details

How to Cite
Nguefack, S., Ngoh, R., Demanou, M., Chiabi, A., Mah, E., Mbassi Awa, H., & Mbonda, E. (2015). Subacute Sclerosing Panencephalitis: A typical case but nearly misdiagnosed. HEALTH SCIENCES AND DISEASE, 16(2). https://doi.org/10.5281/hsd.v16i2.468

References

  1. Schönberger K, Ludwig MS, Wildner M, Weissbrich B. Epidemiology of subacute sclerosing panencephalitis (SSPE) in Germany from 2003 to 2009: A risk estimation. PLoS One. 2013; 9:8(7) doi:10.1371 .
  2. Nguefack F,Tejiokem M, Chiabi A et al. Morbidity And mortality from measles in Cameroonian children: implications for measles control. The open area studies journal 2011,4:7-13.
  3. Saha V, John TJ, Mukundan P et al. High incidence of subacute sclerosing panencephalitis en south India. Epidemiol infect 1990;104(1): 151-6.
  4. Manning L, Laman M, Edoni H et al. Subacute sclerosing panencephalitis in papua new guinean children: the cost of continuing inadequate measles vaccine coverage. PLoS Negl Trop Dis. 2011 ;4 :5(1).
  5. Garg RK. Subacute sclerosing panencephalitis. Postgrad Med J. 2002;78:63-70.
  6. Natan Gadoth. Subacute sclerosing panencephalitis (SSPE)-Past and present, Pathogenesis of Encephalitis. In: Daisuke Hayasaka editors. 2011: 136-52.
  7. Anlar B. Subacute sclerosing panencephalitis and chronic viral encephalitis. Handb clin neurol 2013;112:1183-9.
  8. Serap Teber, Taner Sezer, Mehpare Kafalı, Gülhis Deda. Subacute sclerosing panencephalitis with an atypical presentation: A case report. J Ped Neurol. 2011 ;9 :127–30.
  9. Aydin OF, Senbil N, Kuyucu N, Guer YK. Combined treatment with subcutaneous interferon-alpha, oral Isoprinosine, and lamivudine for subacute sclerosing panencephalitis. J Child Neurol. 2003;18:104-8.
  10. Ravikumar S, Crawford JR. Role of carbamazepine in the symptomatic treatment of subacute sclerosing panencephalitis: a case report and review of the literature. Case Rep Neurol Med. 2013:327647. doi: 10.1155
  11. Bonifas-Galup P, Hamano K, Sebrosa CJ et al. Différents aspects cliniques et électro-encephalographiques de la panencéphalite sclérosante subaigüe (PESS). A propos de 51 cas. Rev Electroencephalogr Neurophysiol Clin. 1983 ; 13 : 224-31.
  12. Zilber N, Rannon L, Alter M, Kahana E. Measles, measles vaccination, and risk of subacute sclerosing panencephalitis (SSPE). Neurol. 1983 ; 33:1558-64.
  13. Brismar J, Gascon GG, von Steyern KV, Bohlega S. Subacute sclerosing panencephalitis: evaluation with CT and MR. Am J Neuroradiol.1996;17:761-72.
  14. Praveen-kumar S, Sinha S, Taly AB et al. Electroencephalographic and imaging profile in a subacute sclerosing panencephalitis (SSPE) cohort: a correlative study. Clin Neurophysiol. 2007,118:1947-54.
  15. Gokcil Z, Odabasi Z, Demirkaya S, Eroglu E, Vural O. Alpha interferon and Isoprinosine in adult-onset subacute sclerosing panencephalitis. J Neurol Sci 1999;162(1):62-4.

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