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Abstract

ABSTRACT
INTRODUCTION. Many studies have showed a high risk of HPV persistence and the development of cervical cancer among immuno deficient patients. In the aim to determine serotypes of human papilloma virus (HPV) of high risk among HIV infected women with cervical intra epithelial lesions, we conducted a prospective and analytic the study at Medical Diagnostic center and in Centre Pasteur of Yaoundé.
METHODOLOGY. We carried out a prospective and analytic study which took 9 months. The study included 112 HIV sexually active infected women. Data of interest were the type of cervical epithelial lesions lesion and its grade and risk factors.
RESULTS. The average age was 38,5 years. 66% of the smear tests were inflammatory and 21% were dysplastic.
71% of the dysplastic lesions were of high grade. In this high grade group, the HPV testing was always negative. The only significant risk factor was the low CD4 count.
CONCLUSION. In Cameroonian HIV infected women, high grade intra epithelial lesions are associated with HPV serotypes that are not highly aggressive, and that therefore can be missed by the ABOOT test.

RÉSUMÉ
INTRODUCTION. De nombreuses études ont montre un risque élevé de persistance du HPV et de développement du cancer du col chez les patientes immunodéprimées
Dans le but de déterminer les Serotypes HPV a haut risque parmi les femmes séropositives au HIV ayant des lésions intra épithéliales, nous avons entrepris une étude prospective et analytique au laboratoire Médical center et au Centre Pasteur de Yaoundé.
MÉTHODOLOGIE. Il s`agit d`une étude prospective et analytique qui s`est étalée sur 9 mois. Nous avons inclus 112 patientes séropositives, actives sexuellement. Les variables étudiées étaient le type de lésion et le grade ainsi que les facteurs de risques.
RÉSULTATS. L`âge moyen des patientes était de 38,5 ans. 66% des frottis étaient inflammatoires ( 66%) et 21% étaient dysplasiques. Chez les 21 patientes ayant une dysplasie cervicale, 15 (71%) présentaient une dysplasie de haut grade H-SIL. Dans ce groupe, le test HPV a été constamment négatif, et le seul facteur de risque significatif était le taux bas de CD4.
CONCLUSION. Chez les patientes HIV positives, les lésions de haut grade sont dues à des Serotypes HPV peu agressifs, donc non visualises par le test ABOOTT qui ne détecte que les Serotypes a haut risque.

 

Article Details

How to Cite
Kabeyene, A. C. O., Bongning, D., Mendimi Nkodo, M., Sando, Z., Doh, A., Fewou, A., & Essame Oyono, J. (2015). Sérotypes de Papillomavirus Humain à Haut Risque chez les Patientes Séropositives au VIH Présentant des Lésions Intra Épithéliales Cervicales. HEALTH SCIENCES AND DISEASE, 16(2). Retrieved from https://www.hsd-fmsb.org/index.php/hsd/article/view/524

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